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Luis Gabriel Brieba de Castro

 
Postion: Investigador 3A, SNI I.
Telephone: +52 (462) 6239663
E-mail: lgbrieba@ira.cinvestav.mx
Langebio
Laboratory of Structural Biochemistry
 
Education & training
 
2005    Postdoctorate in Structural Biochemistry, Harvard Medical School, Boston, USA
2001    Ph.D. in Biochemistry, U. of Texas Health Science Center, San Antonio, USA
1993    B.A. in Biochemistry, ITESM, Guaymas, México.
 
Reseach interests
  • Nucleic acid metabolism in organelles
  • Structural Biochemistry by X-ray Crystallography
  • Protein Engineering
 
Recent publications
  • Teresa Mejia-Castillo, Maria E. Hidalgo-Lara, Luis G. Brieba, Jaime Ortega-López. Purification, characterization and modular organization of a cellulose-binding protein, CBP105, a processive beta-1,4-endoglucanase from Cellulomonas flavigena. Biotechnol Lett. In press
  • Luis G. Brieba Robert J. Kokoska, Katarzyna Bebenek, Tom A. Kunkel, and Tom Ellenberger (2005) A lysine residue in the fingers subdomain of T7 DNA polymerase modulates the miscoding potential of 8-oxo-7,8-dihydroguanosine. Structure13, 1653.
  • Luis G. Brieba, Brandt F. Eichman, Robert J. Kokoska, Sylvie Doublié, Tom A. Kunkel, and Tom Ellenberger (2004) Structural basis for the dual coding potential of 8-oxoguanosine during nucleotide insertion and elongation by a high fidelity DNA polymerase. EMBO Journal 23, 3452.
  • Srabani Mukherjee, Luis G. Brieba, and Rui Sousa (2002) Structural Transitions Mediating Transcription Initiation by T7 RNA Polymerase. Cell 110, 81.
  • Luis G. Brieba, and Rui Sousa (2001) T7 Promoter Release Mediated by DNA Scrunching. EMBO Journal 20: 6826.