es-MX English (United States)




Artículos de investigación

  • Cynthia Paola Rangel-Chávez, Edgardo Galán-Vásquez, Azucena Pescador-Tapia, Luis Delaye, Agustino Martínez-Antonio (2021) RNA polymerases in strict endosymbiont bacteria with extreme genome reduction show distinct erosions that might result in limited and differential promoter recognition. PLoS One 2021 Jul 29;16(7):e0239350. doi: 10.1371/journal.pone.0239350. eCollection. Link.
  • Luis Diaz-Garcia, Luis Fernando Garcia-Ortega, Maria González-Rodríguez, Luis Delaye, Massimo Iorizzo and Juan Zalapa (2021) Chromosome-Level Genome Assembly of the American Cranberry (Vaccinium macrocarpon Ait.) and Its Wild Relative Vaccinium microcarpum. Front. Plant Sci., 10 February 2021. Link.
  • Andrés Moya, José L. Oliver, Miguel Verdú, Luis Delaye, Vicente Arnau, Pedro Bernaola-Galván, Rebeca de la Fuente, Wladimiro Díaz, Cristina Gómez-Martín, Francisco M. González, Amparo Latorre, Ricardo Lebrón & Ramón Román-Roldán. Driven progressive evolution of genome sequence complexity in Cyanobacteria. Scientific Reports volume 10, Article number: 19073 (2020). Link.
  • González-Pacheco, B.E., Delaye, L., Ochoa, D. et al. Changes in the GN/GCof the M segment show positive selection and recombination of one aggressive isolate and two mild isolates of tomato spotted wilt virus. Virus Genes (2020). Link.
  • Delaye L. Gene Coding for GPI Biosynthesis in Pneumocystis Experienced Relaxed Selection: A Follow-up Study. OBM Genetics 2019;3(3):11; doi:10.21926/obm.genet.1903083. Link.
  • Avila de Dios, E., Delaye, L. & Simpson, J. BMC Genomics (2019) Transcriptome analysis of bolting in A. tequilana reveals roles for florigen, MADS, fructans and gibberellins. 20: 473. Link.
  • Trasviña-Arenas CH, David SS, Delaye L, Azuara-Liceaga E, Brieba LG (2019) Evolution of Base Excision Repair in Entamoeba histolytica is shaped by gene loss, gene duplication, and lateral gene transfer. DNA Repair (Amst). Feb 22;76:76-88. doi: 10.1016/j.dnarep.2019.02.009. Link.
  • Delaye L, Ruiz-Ruiz S, Calderon E, Tarazona S, Conesa A, Moya A. (2018) Evidence of the Red-Queen hypothesis from accelerated rates of evolution of genes involved in biotic interactions in Pneumocystis. Genome Biol Evol. Jun 11. doi: 10.1093/gbe/evy116. Link.
  • Martínez-Cano DJ, Bor G, Moya A, Delaye L. (2018) Testing the Domino Theory of Gene Loss in Buchnera aphidicola: The Relevance of Epistatic Interactions. Life (Basel). May 29;8(2). pii: E17. doi: 10.3390/life8020017. Link.
  • Ricardo Ortega, Luis Delaye, Cuauhtemoc Lopez-Martin, Arturo Chavoya (2018) SARELI: Sequence Alignment by Radial Evaluation of Local Interactions. Current Bioinformatics. Volume 13. DOI : 10.2174/1574893613666180130143055. Link.
  • González-Domenech CM, Viciana I, Delaye L, Mayorga ML, Palacios R, de la Torre J, Jarilla F, Castaño M, Del Arco A, Clavijo E, Santos J. (2018) Emergence as an outbreak of the HIV-1 CRF19_cpx variant in treatment-naïve patients in southern Spain. PLoS One. Jan 8;13(1):e0190544. doi: 10.1371/journal.pone.0190544. Link.
  • Cecilio Valadez-Cano, Roberto Olivares-Hernández, Osbaldo Resendis-Antonio, Alexander DeLuna and Luis Delaye (2017) Natural selection drove metabolic specialization of the chromatophore in Paulinella chromatophora. BMC Evolutionary Biology. DOI: 10.1186/s12862-017-0947-6. Link.
  • Pérez-Zamorano B, Vallebueno-Estrada M, Martínez González J, García Cook A, Montiel R, Vielle-Calzada JP and Delaye L (2017) Organellar genomes from a ∼5,000 years old archaeological maize sample are closely related to NB genotype. Genome Biology and Evolution. Mar 17. doi: 10.1093/gbe/evx048. Link.
  • Rendón-Anaya M, Montero-Vargas JM, Saburido-Álvarez S, Vlasova A, Capella-Gutierrez S, Ordaz-Ortiz JJ, Aguilar OM, Vianello-Brondani RP, Santalla M, Delaye L, Gabaldón T, Gepts P, Winkler R, Guigó R, Delgado-Salinas A, Herrera-Estrella A. (2017) Genomic history of the origin and domestication of common bean unveils its closest sister species. Genome Biol. Mar 29;18(1):60. doi: 10.1186/s13059-017-1190-6. Link.
  • Paulina Guzmán-Guzmán, Mario Iván Alemán-Duarte, Luis Delaye, Alfredo Herrera-Estrella and Vianey Olmedo-MonfilEmail (2017) Identification of effector-like proteins in Trichoderma spp. and role of a hydrophobin in the plant-fungus interaction and mycoparasitism. BMC GeneticsBMC series. 18:16. DOI: 10.1186/s12863-017-0481-y. Link.
  • Diana Ascencio, Soledad Ochoa,  Luis Delaye and Alexander DeLuna (2017) Increased rates of protein evolution and asymmetric deceleration after the whole-genome duplication in yeasts. BMC Evolutionary Biology | DOI: 10.1186/s12862-017-0895-1. Link.
  • Maria D. Rodríguez-Torres, Africa Islas-Robles,  Ismael Hernandez-Gonzalez,  Zulema Gomez Lunar,  Luis J. Delaye,  Valeria Souza, Michael Travisano and  Gabriela Olmedo-Alvarez (2017) Phenotypic microdiversity and phylogenetic signal analysis of traits related to social interaction in Bacillus spp. from sediment communities. Front. Microbiol. | doi: 10.3389/fmicb.2017.00029. Link.
  • Obed Ramírez-Sánchez, Paulino Pérez-Rodríguez, Luis Delaye, Axel Tiessen, (2016) Plant Proteins Are Smaller Because They Are Encoded by Fewer Exons than Animal Proteins. Genomics Proteomics Bioinformatics 14:357–370. Link.
  • Delaye L, Valadez-Cano C, Pérez-Zamorano B. How Really Ancient Is Paulinella Chromatophora?. PLOS Currents Tree of Life. 2016 Mar 15 . Edition 1. doi: 10.1371/currents.tol.e68a099364bb1a1e129a17b4e06b0c6b. Link.
  • Vlasova, A., et al. (2016). Genome and transcriptome analysis of the Mesoamerican common bean and the role of gene duplications in establishing tissue and temporal specialization of genes. Genome Biology, 2016; 17 (1) DOI: 10.1186/s13059-016-0883-6. Link.
  • Schmoll M. et al. (2016) The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species. Microbiol. Mol. Biol. Rev. vol. 80 no. 1 pp. 205-327. doi: 10.1128/MMBR.00040-15. Link.
  • Ramírez-Puebla ST, Servín-Garcidueñas LE, Ormeño-Orrillo E, Vera-Ponce de León A, Rosenblueth M, Delaye L, Martínez J, Martínez-Romero E. (2016) A response to Lindsey et al. "Wolbachia pipientis should not be split into multiple species: A response to Ramírez-Puebla et al.". Syst Appl Microbiol. May;39(3):223-225. doi: 10.1016/j.syapm.2016.03.004. Link.
  • Ramírez-Puebla ST, Servín-Garcidueñas LE, Ormeño-Orrillo E, Vera-Ponce de León A, Rosenblueth M, Delaye L, Martínez J, Martínez-Romero E. (2015) Species in Wolbachia? Proposal for the designation of 'Candidatus Wolbachia bourtzisii', 'Candidatus Wolbachia onchocercicola', 'Candidatus Wolbachia blaxteri', 'Candidatus Wolbachia brugii', 'Candidatus Wolbachia taylori', 'Candidatus Wolbachia collembolicola' and 'Candidatus Wolbachia multihospitum' for the different species within Wolbachia supergroups. Syst Appl Microbiol. Jul 2. pii: S0723-2020(15)00087-9. doi: 10.1016/j.syapm.2015.05.005. Link.
  • Álvarez-Canales G, Arellano-Álvarez G, González-Domenech CM, de la Cruz F, Moya A, Delaye L. (2015) Identification of Xenologs and Their Characteristic Low Expression Levels in the Cyanobacterium Synechococcus elongatus. J Mol Evol. 10.1007/s00239-015-9684-x. Link.
  • David J. Martínez-Cano, Mariana Reyes-Prieto, Esperanza Martínez-Romero, Laila P. Partida-Martínez, Amparo Latorre, Andrés Moya and Luis Delaye (2015) Evolution of small prokaryotic genomes. Front. Microbiol., 06 January 2015 | doi: 10.3389/fmicb.2014.00742. Link.
  • Encinas D, Garcillán-Barcia MP, Santos-Merino M, Delaye L, Moya A, de la Cruz F. (2014) Plasmid conjugation from proteobacteria as evidence for the origin of xenologous genes in cyanobacteria. J Bacteriol. Apr;196(8):1551-1559. Link.
  • Daniel Cerqueda-García, León P Martínez-Castilla, Luisa I Falcón and Luis Delaye (2013) Metabolic analysis of Chlorobium chlorochromatii CaD3 reveals clues of the symbiosis in ‘Chlorochromatium aggregatum’. ISMEJ. Link.
  • María Velasco A, Becerra A, Hernández-Morales R, Delaye L, Jiménez-Corona ME, Ponce-de-Leon S, Lazcano A (2013) Low complexity regions (LCRs) contribute to the hypervariability of the HIV-1 gp120 protein. J Theor Biol. Dec 7;338:80-6. Link.
  • Delaye L, Garcia-Guzman G, Heil M (2013) Endophytes versus biotrophic and necrotrophic pathogens - are fungal lifestyles evolutionarily stable traits? Fungal Diversity. Link.
  • Rendón-Anaya M, Delaye L, Possani LD, Herrera-Estrella A (2012) Global Transcriptome Analysis of the ScorpionCentruroides noxius: New Toxin Families and Evolutionary Insights from an Ancestral Scorpion Species. PLoS ONE, 7(8): e43331. Link.
  • Tiessen A, Pérez-Rodríguez P, Delaye-Arredondo LJ. (2012) Mathematical modeling and comparison of protein size distribution in different plant, animal, fungal and microbial species reveals a negative correlation between protein size and protein number, thus providing insight into the evolution of proteomes. BMC Res Notes, Feb 1;5:85. Link.
  • Delaye L and Moya A (2011) Abundance and distribution of the highly iterated palindrome 1 (HIP1) among prokaryotes. Mob Genet Elements, 1(3):159-168. Link.
  • Faure E, Delaye L, Tribolo S, Levasseur A, Seligmann H, Barthelemy R-M. (2011) Probable presence of an ubiquitous cryptic mitochondrial gene on the antisense strand of the cytochrome oxydase I gene. Biology Direct 2011, 6:56. Link.
  • Luis Delaye, Carmen M Gonzalez-Domenech, Maria P Garcillan-Barcia, Juli Pereto, Fernando de la Cruz and Andres Moya (2011) Blueprint for a minimal photoautotrophic cell: conserved and variable genes in Synechococcus elongatus PCC 7942. BMC Genomics. 12:25. Link.
  • Delaye L, Moya A. (2010) Evolution of reduced prokaryotic genomes and the minimal cell concept: variations on a theme. Bioessays. 32:281-287. Link.
  • Delaye, L., Gil, R., Pereto, L., Latorre, A., Moya, A. (2010) Life with a few genes: a survey on naturally evolved reduced genomes. Open Evolution Journal.4:12-22. Link.
  • Rosario Gil, Eugeni Belda, María José Gosalbes, Luis Delaye, Agnès Vallier, Carole Vincent-Monégat, Abdelaziz Heddi, Francisco J. Silva, Andrés Moya and Amparo Latorre. (2008) Massive presence of Insertion Sequences in the genome of SOPE, the primary endosymbiont of the rice weevil Sitophilus oryzae. International Microbiology 11:41-48. Link.
  • Delaye, L., DeLuna, A., Lazcano, A., and Becerra, A. (2008) The origin of a novel gene through overprinting in Escherichia coli. BMC Evolutionary Biology 8:31. Link.
  • Becerra, A., Delaye, L., Lazcano, A. and Orgel, L. (2007) Protein disulfide oxidoreductases and the evolution of thermophily: was the last common ancestor a heat-loving microbe? Journal of Molecular Evolution 65: 296-303. Link.
  • Becerra, A., Delaye, L., Islas, A., and Lazcano A. (2007) Very early stages of biological evolution related to the nature of the last common ancestor of the three major cell domains. Annual Review of Ecology, Evolution  and Systematics 38: 361-379. Link.
  • Delaye L, Becerra A, Orgel L, and Lazcano A. (2007) Molecular evolution of peptide methionine sulfoxide reductases (MsrA and MsrB): on the early development of a mechanism that protects against oxidative damage. Journal of Molecular Evolution. 64:15-32. Link.
  • Martinez-Perez F, Duran-Gutierrez D, Delaye L, Becerra A, Aguilar G, Zinker S. (2007) Loss of DNA: a plausible molecular level explanation for crustacean neuropeptide gene evolution. Peptides. 28:76-82. Link.
  • Delaye L, Becerra A, and Lazcano A. (2005) The Last Common Ancestor: what's in a name? Origin of Life and Evolution of the Biosphere. 35: 537-554. Link.
  • Delaye L and Lazcano A. (2004) Prebiological evolution and the physics of the origin of life. Physics of Life Reviews, 2: 47-64. Link.
  • Islas S, Velasco AM, Becerra A, Delaye L and Lazcano A. (2003) Hyperthermophily and the origin and earliest evolution of life. International Microbiology. 6: 87-94. Link.


Capítulos de libro

  • Gilberto P. Morales and Luis Delaye. Was LUCA a Hyperthermophilic Prokaryote? The Impact-Bottleneck Hypothesis Revisited. In "Astrobiology and Cuatro Ciénegas Basin as an Analog of Early Earth". Editors Valeria Souza, Antígona Segura and Jamie S. Foster. Springer Nature Switzerland AG 2020. Link.
  • Delaye L, Vargas C, Latorre A, Moya A. Inferring Horizontal Gene Transfer with DarkHorse, Phylomizer, and ETE Toolkits. Methods Mol Biol. 2020;2075:355-369. doi: 10.1007/978-1-4939-9877-7_25. Link.
  • Luis José Delaye Arredondo, Arturo Becerra Bracho (2018) Evolución temprana de la vida en la Tierra. En "Genética Clínica". Victoria del Castillo Ruiz, Rafael Dulijh Uranga Hernández, Gildardo Zafra de la Rosa (coordinadores). Manual Moderno Editores, México, páginas: 625-631. ISBN: 9786074486971.
  • Luis José Delaye Arredondo (2015) El gran salto de Darwin y la revolución de la parentalidad humana. En "Parentalidad I concierto con la vida". Margarita Lagarde Lozano, Luis Alberto Vargas Guadarrama, Ma. Guadalupe Méndez Cárdenas (coordinadores). Castellano Editores, México, páginas: 17-58.
  • Lazcano, A., Becerra, A. and Delaye, L. Alarmones. In Margulis, L. Asikainen, C.A. and Krumbie, W.E. (eds) Chimeras and Consciousness: Evolution of the Sensory Self. MIT (2011). Link.
  • Neef, Alexander, Delaye, Luis, López-Sánchez, María José, Peretó, Juli, Latorre, Amparo, and Moya, Andrés (2010) Stages of metabolic adaptation of endosymbiotic bacteria. In von Jürgen Heesemann, Michael Hensel (eds) Nova Acta Leopoldina, pp. 141-149.
  • C.M. González-Domenech, J. Puchaka, V.A.P. Martins dos Santos, J. Peretó, A. Moya and L. Delaye (2010) Metabolic reconstruction of Synechococcus elongatus towards a minimal photoautotrophic cell. In Antonio Mendez-Vilas (ed) Microorganisms in Industry and Environment From Scientific and Industrial Research to Consumer Products (World Scientific Publishing Co), pp. 699.
  • Luis Delaye, Manel Porcar y Andrés Moya (2009) La biología sintética frente al reto de la energía. Rubio J.L. (ed) XVII Foro Universitario Juan Luis Vives, Ayuntamiento de Valencia, España.
  • Cortez, D., Delaye, L., Lazcano, A., Becerra, A. (2009) Composition-based methods to identify horizontal gene transfer. Methods Mol Biol. 532:215-225. Link.
  • Islas, S., Velasco, A. M., Becerra, A., Delaye, L., and Lazcano, A. (2007) Extremophiles and the origin of life. In Charles Gerday and Nicolas Glansdorff (eds) Phyisiology and Biochemistry of Extremophiles (ASM Press, Washington, D.C.), pp. 3-10.
  • Luis Delaye, Arturo Becerra (2005) Filogenias moleculares. En "Manual de Prácticas de Genética y Cuaderno de Trabajo", Prensa de Ciencias.
  • Delaye, L., Becerra A., Velasco A.M., Islas S., Lazcano A. (2004) Prebiotic Organic Synthesis and the Emergence of Life: From the Miller Experiment to the Start of Biological Evolution. In: Seckbach J., Chela-Flores J., Owen T., Raulin F. (eds) Life in the Universe. Cellular Origin and Life in Extreme Habitats and Astrobiology, vol 7. Springer, Dordrecht.
  • Delaye, L., Becerra, A., And Lazcano, A. (2004) The Nature of the Last Common Ancestor. In Lluis Ribas de Pouplana (ed.) The Genetic Code and the Origin of Life (Springer US). pp. 34-47.
  • Delaye, L., Vázquez H., Lazcano A. (2001) The Cenancestor and Its Contemporary Biological Relics: The Case of Nucleic Acid Polymerases. In: Chela-Flores J., Owen T., Raulin F. (eds) First Steps in the Origin of Life in the Universe. Springer, Dordrecht.


Memorias de congresos científicos 

  • Emmanuel Ávila de Dios, Octavio Martinez, Luis Delaye Arredondo y June Simpson Williamson (2013). Transcriptome analysis and tissue specific expression in Agave tequilanaA. striata and A. victoriae-reginae. Bioveg 2013. ISBN: 978-959-16-2045-3.
  • Javier Carpinteyro, Zurisadai Muñoz, Mario Alemán, David Martínez, Cecilio Valadez, Luis Delaye (2012). Evolurionary Analysis of Genes and Genomes. Conference proceedings ISUM, 3rd International Supercomputing Conference in México. Universidad de Guadalajara. pp: 7-12. ISBN: 978-607-450-661-7.
  • Delaye, L. and Lazcano, A. (2000) RNA-binding peptides as molecular fossils In J.Chela-Flores, G. Lemerchand, and J. Oró (eds) Astrobiology: Origins from the Big-Bang to Civilisation Proceedings of the First Ibero-American School of Astrobiology (Klüwer Academic Publishers, Dordrecht), pp. 285-288. 


Divulgación de la ciencia 

  • Luis José Delaye Arredondo (2021) ¿Cuántas variantes del SARS-CoV-2 hay en México? Epidemiología Genómica del Coronavirus. Avance y Perspectiva. Link.
  • Luis José Delaye Arredondo (2020) ¿Tiene el coronavirus SARS-CoV-2 un origen natural? Revisita. Avance y Perspectiva. Link.
  • Luis José Delaye Arredondo (2020) ¿Tiene el coronavirus SARS-CoV-2 un origen natural? Avance y Perspectiva. Link.
  • Luis Delaye, Cecilio Valadez Cano, Bernardo Pérez Zamorano (2017) De simbiosis y relojes moleculares. Herreriana, Año 13, No. 2, pp. 25 - 28. Link.
  • Arturo Becerra, Luis Delaye (2015) El ancestro universal, una reconstrucción inacabada. METODE Science Studies Journal. Universitat de Valencia. Num 87. DOI:10.7203/metode.6.4981. Link.
  • Luis Delaye (2014) Biologías Exóticas. Revista digital: "Hacia el Espacio". Ed. 26. Link.
  • David Martínez, Cecilio Valadez, Martha Rendón, Luis Delaye (2013) Evolución, moléculas, hipótesis y cómputo. Ide@as CONCYTEG. 8(95): Mayo, 2013 ISSN:2007-2716. Link.
  • Delaye L and Becerra A (2012) Cenancestor, The Last Universal Common Ancestor. Evo Edu Outreach. 5:382-388.  Link.
  • Luis Delaye (2007) Evolución Darwiniana: una revolución en lo pequeño. Lunes de ciencia, pp. 18-22. Universidad de Guanajuato.



  • Arturo Becerra and Luis Delaye (eds.) The quest for simple life. Frontiers Research Topic (2015)Link. 
  • Luis Delaye. Cenancestor; Common Ancestor; Last Universal Common Ancestor. In: Enciclopedya of Astrobiology. Muriel Gargaud (Editor in Chief), Ricardo Amils, José Cernicharo Quintanilla, Henderson James (Jim) Cleaves, William M. Irvine, Daniele L. Pinti and Michel Viso (Eds.) Springer-Verlag Berlin Heidelberg 2011. pages: C:279,351; L:906-909. Link.


Videos de divulgación de la ciencia 

  • Luis Delaye (2021) Tras las variantes del coronavirus Link.
  • Luis Delaye (2020) ¿Tiene el coronavirus SARS-CoV-2 un origen natural? LinkLinkLinkLinkLink.


Conferencias videograbadas

  • Luis Delaye (2021) Diversidad genética del SARS-CoV-2 en México. LinkLink.
  • Luis Delaye (2018) El origen de los genes - El Colegio Nacional. Link.
  • Luis Delaye (2015) The unfinished reconstruction of LUCA - The major transitions in evolution. Link.
  • Luis Delaye (2012) Darwin como un filósofo revolucionario - sensu Gould S.J. Link.