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Dr. Rául Álvarez Venegas
BIOTECHNOLOGY
Dr. Miguel Ángel Gómez Lim
Position: Investigador 3E, SNI III.
Telephone: +52 (462) 6239679
E-mail: mgomez@ira.cinvestav.mx
Laboratory of Tropical Plants and Human Health

Education & training

1987   Postdoctorate in Plant Molecular Biology. Department of Biology,
          University of California Los Angeles, USA
1986   Ph.D. in Plant Molecular Biology, Department of Botany. University of Edinburgh. United Kingdom
1982   Faculty of Sciences, National University of Mexico.

Research interests

  • Molecular Pharming. Production of biopharmaceutical proteins in plants.
  • Improvement of tropical crops by Biotechnology/Genetic Engineering.
  • Analysis of plant-fungus interaction using Proteomic tools.
Recent publications
  • Laura Uribe-Campero, Alberto Monrroy-García, Ana L. Durán-Meza, María V. Villagrana-Escareño, Jaime Ruíz-García, Jesús Hernández, Hector G. Núñez-Palenius and Miguel A. Gómez-Lim. Plant-based porcine reproductive and respiratory syndrome virus VLPs induce an immune response in mice. Research in Veterinary Science. 2015, Vol. 102: 59-66. DOI: 10.1016/j.rvsc.2015.07.012.
  • Lina Escobar-Tovar, Denis Magaña-Ortíz, Francisco Fernández, Mauricio Guzmán-Quesada, Jorge A. Sandoval-Fernández, Elizabeth Ortíz-Vázquez, Achim Loske and Miguel A. Gómez-Lim. Efficient transformation of Mycosphaerella fijiensis by underwater shock waves. Journal Microbiological Methods. 2015, Vol. 119: 98-105. DOI:10.1016/j.mimet.2015.10.006.
  • Lina Escobar Tovar, Mauricio Guzmán Quesada, Jorge A. Sandoval-Fernández and Miguel A. Gómez-Lim. Comparative analysis of the in vitro and in planta secretome from Mycosphaerella fijiensis isolates. Fungal Biology, 2015, Vol. 11: 447-470. DOI: 10.1016/j.funbio.2015.01.002.
  • Nancy Coconi-Linares, Elizabeth Ortiz-Vázquez, Francisco Fernández, Achim M. Losk and Miguel A. Gómez-Lim. Recombinant expression of four oxidoreductases in Phanerochaete chrysosporium improves degradation of phenolic and non-phenolic substrates. Journal of Biotechnology. 2015, Vol. 209: 76-84. DOI: 10.1016/j.jbiotec.2015.06.401.
  • Escobar Tovar, LM., Guzmán Quesada, M., Sandoval Fernández, J.A. and Gómez-Lim, MA. (2014) Comparative analysis of the in vitro and in planta secretome from Mycosphaerella fijiensis isolates. Fungal Genet and Biol. (Manuscript accepted)
  • Coconi-Linares N, Magaña-Ortíz D, Guzmán-Ortiz DA, Ortíz-Vázquez E, Fernandez F, Loske AM and Gómez Lim MA. (2014) High-yield production of manganese peroxidase, lignin peroxidase, and versatile peroxidase in Phanerochaete chrysosporium. Applied Microbiology and Biotechnology 98, 9283–9294.
  • Tinajero JC, Ascencio D, Marquina B, Barrios J, Gutierrez MC, Gomez Lim M, Hernández Pando R. (2014) Induction of bone formation in abdominal implants constituted by collagen sponges embedded with plant-based human transforming growth factor family proteins in ectopic dog model. Journal of Experimental Ortophedics. 1, 11.
  • Loske AM, Fernández F, Magaña-Ortíz D, Coconi-Linares N, Ortíz-Vázquez E and Gómez Lim MA. (2014) Tandem shock waves to enhance genetic transformation of Aspergillus niger. Ultrasonics 54, 1656-1662.
  • Rivera A.L, Magaña-Ortíz D, Gomez Lim, M.A., Fernández, F., Loske, A.M. (2014) When the boundaries between physics ans biology blur: A promising future for fungi as producers of valuable recombinant proteins. Physics of Life Reviews. 11, 217–219.
  • Padilla, G., Pérez, J.A., Perea-Arango, I., Moon, P.A., Gómez Lim, M.A., Borges, A.A., Expósito-Rodríguez, M. and Litz, R.E. (2013) Agrobacterium tumefaciens-mediated transformation of 'Brewster' ('Chen Tze') litchi (Litchi chinensis Sonn.) with the PISTILLATA cDNA in antisense. In Vitro Cellular and Develomental Biology-Plant. 49, 510–519.
  • Rivera A.L, Magaña-Ortíz D, Gomez Lim, M.A., Fernández, F., Loske, A.M. (2014) Physical methods for genetic transformation of fungi and yeast. Physics of Life Reviews 11, 184-203.
  • Monroy García, A., Gómez Lim, M.A., Weiss Steider, B., Hernández Montes, J., Huerta Yepez, S., Rangel Santiago, J.F., Santiago Osorio, E. and Mora García, M.L. (2013) Immunization with an HPV-16 L1-based chimeric virus-like particle containing HPV-16 E6 and E7 epitopes elicits long-lasting prophylactic and therapeutic efficacy in an HPV-16 tumor mice model. Arch Virol. 159, 291-305.
  • Magaña Ortiz D, Coconi Linares N, Ortiz Vazquez E, Fernandez F, Loske AM and Gomez Lim, M.A. (2013) A novel and highly efficient method for genetic transformation of fungi employing shock waves. Fungal Genet and Biol. 56, 9-16.
  • Coconi Linares N, Ortega Dávila E, García Machorro J, García Cordero J, Cedillo-Barrón L. and Gómez Lim MA. (2013) Targeting of envelope domain III protein of DENV type 2 to DEC-205 receptor elicits neutralizing antibodies in mice. Vaccine 31, 2366-2371.
  • de los Santos-Villalobos S, Guzmán-Ortiz DA, Gómez-Lim MA, Délano-Frier JP, de-Folter S, Sánchez-García P and Peña-Cabriales JJ. (2013) Potential use of Trichoderma asperellum (Samuels, Liechfeldt et Nirenberg) T8a as a biological control agent against anthracnose in mango. Biological Control 64, 37–44.
  • Loza-Rubio E, Rojas-Anaya E, López J, Olivera-Flores MT, Gómez-Lim MA, Tapia-Pérez G. (2012) Induction of a protective immune response to rabies virus in sheep after oral immunization with transgenic maize, expressing the rabies virus glycoprotein. Vaccine 30, 5551–5556.
  • Rivera, A.L, Gomez Lim, M.A., Fernández, F., Loske, A.M. (2012) Physical methods for genetic plant transformation. Physics of Life Reviews. 9, 308–345.